Pyrimidine nucleosides
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.98% | 500 MG
2'-Deoxyuridine is a brain-penetrant pyrimidines nucleotide associated with nervous system diseases. It can increase chromosome breakage and decrease thymidylate synthetase activity. This product serves as a precursor in the synthesis of Edoxudine and is an analogue of 5-ethynyl-2'-deoxyuridine. It has shown promise in Alzheimer's disease (AD) research by reducing microglial activation and improving oxidative stress damage through modulation of glycolytic metabolism on Aβ25-35-induced brain injury.
- Associated with nervous system diseases.
- Increases chromosome breakage.
- Decreases thymidylate synthetase activity.
- Precursor in the synthesis of edoxudine.
- Analogue of 5-ethynyl-2'-deoxyuridine.
- Reduces microglial activation.
- Improves oxidative stress damage.
Medchemexpress LLC 2'-deoxycytidine-2'-13C | >98.0% | 228.21 g/mol | C8 13CH13N3O4 | 1 MG
13C-labeled 2'-deoxycytidine supplied as a research-grade stable isotope standard for analytical and tracer studies. Supplied in a small 1 mg pack with reported high purity, it is intended for use in metabolite tracing, mass spectrometry calibration, and other analytical applications.
- Stable isotope labeled (13C) standard for analytical methods.
- Suitable for metabolite tracing and mass spectrometry quantitation.
- High reported purity (>98.0%).
- Supplied in a small research pack suitable for analytical use.
- Provided as a solid, easy to store and handle in laboratory settings.
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.2% | 100 MG
2'-Deoxyuridine | 951-78-0 | 99.2% | 100 MG
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.98% | 50 MG
2'-deoxyuridine is a brain-penetrant pyrimidines nucleotide associated with nervous system diseases. It can increase chromosome breakage and decrease thymidylate synthetase activity. This product is a precursor in the synthesis of Edoxudine and an analogue of 5-ethynyl-2'-deoxyuridine, EdU. It reduces microglial activation and improves oxidative stress damage by modulating glycolytic metabolism on Aβ25-35-induced brain injury, showing promise for Alzheimer's disease (AD) research.
- Brain-penetrant pyrimidines nucleotide
- Associated with nervous system diseases
- Increases chromosome breakage
- Decreases thymidylate synthetase activity
- Reduces microglial activation and improves oxidative stress damage by modulating glycolytic metabolism on Aβ25-35-induced brain injury
- Promising for Alzheimer's disease (AD) research
- Appearance: Solid
- Color: White to off-white
Apexbio Technology LLC 5-Ethynyl-2'-deoxyuridine (5-EdU), 1g CAS# 61135-33-9
5-Ethynyl-2'-deoxyuridine (5-EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. 5-EdU can be used as a replacement for BrdU (5-Bromo-2'-deoxyuridine) to measure de novo DNA synthesis during the S-phase of the cell cycle through click chemistry. Click chemistry is a method of covalently coupling an azide with an alkyne. 5-EdU has an alkyne handle that can be detected using azide-containing fluorescent probes through a highly efficient click chemistry reaction. In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-EdU-labelled cells may be isolated to determine the transcript of cells, from neural cancer or tissues that have undergone division in vitro and in vivo. Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC 4-thio-2'-deoxyuridine | 5580-20-1 | MFCD00058457 | 99.8% | 244.27 g/mol | C9H12N2O4S | 100 MG
4-Thio-2'-deoxyuridine is a sulfur-substituted deoxyuridine nucleoside analogue used in biochemical and nucleic acid research, including studies of nucleic acid chemistry and incorporation into oligonucleotides. It has molecular formula C9H12N2O4S, molecular weight 244.27 g/mol, and a reported purity of 99.78%.
- Sulfur-substituted deoxyuridine analogue useful for nucleic acid studies.
- High reported purity (99.8%), suitable for analytical and synthetic applications.
- Available in multiple pack sizes for research-scale work.
- Provided with certificate of analysis and safety data sheet for quality and handling.
- Offered in solid form and as 10 mM DMSO solution for convenient use.
Medchemexpress LLC KTX-951 | 2573298-36-7 | 99.6% | 850.95 | 1 MG
KTX-951 is an orally active PROTAC degrader targeting IRAK4 and IMiD (Ikaros/Aiolos) substrates. It exhibits a Kd of 3.5 nM for IRAK4, with DC50 values of 13 nM, 14 nM, and 13 nM for IRAK4, Ikaros, and Aiolos, respectively. This compound also shows an IC50 of 35 nM for OCl-Ly10 CTG and demonstrates antitumor activity.
- Orally active PROTAC degrader
- Targets IRAK4 and IMiD (Ikaros/Aiolos) substrates
- Kd of 3.5 nM for IRAK4
- Molecular weight: 850.95
- Formula: C46H52F2N8O6
- Appearance: Solid, light yellow to yellow
- Purity: 99.60%
- Soluble in DMSO at 50 mg/mL (58.76 mM)
- Oral bioavailability in rats: 22% at 10 mg/kg
- Oral bioavailability in dogs: 57% at 10 mg/kg
Cambridge Isotope Laboratories 2'-DEOXYURIDINE:AMMONIUM SALT 90% CHEMICAL PURITY (13C9, 98-99%; 15N2, 98-99%) (IN SOLN), 100 UMOL
2'-DEOXYURIDINE:AMMONIUM SALT 90% CHEMICAL PURITY (13C9, 98-99%; 15N2, 98-99%) (IN SOLN), 100 UMOL
Medchemexpress LLC 2'-Deoxyuridine | 951-78-0 | 99.98% | 1 G
2'-Deoxyuridine is a brain-penetrant pyrimidine nucleotide associated with nervous system diseases. It can increase chromosome breakage and reduce thymidylate synthetase activity. This compound serves as a precursor in the synthesis of Edoxudine and is an analogue of 5-ethynyl-2'-deoxyuridine. It has demonstrated the ability to lessen microglial activation and enhance oxidative stress damage by modulating glycolytic metabolism in brain injury models, indicating its potential for Alzheimer's disease research.
- Brain-penetrant pyrimidine nucleotide.
- Associated with nervous system diseases.
- Can increase chromosome breakage.
- Reduces thymidylate synthetase activity.
- Precursor in synthesis.
- Analogue of other compounds.
- Reduces microglial activation.
- Improves oxidative stress damage.
- Modulates glycolytic metabolism in brain injury.
- Promising for Alzheimer's disease research.
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 100.0% | 5 G
2'-Deoxycytidine, a deoxyribonucleoside, can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Deoxyribonucleoside
- Inhibits biological effects of bromodeoxyuridine (Brdu)
- Essential for the synthesis of nucleic acids
- Can be used for cancer research
- Inhibits tumor growth in mice
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 99.95% | 1 G
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of Brdu.
- Essential for nucleic acid synthesis.
- Used in cancer research.
- Inhibits tumor growth in vivo.
Medchemexpress LLC 2'-Deoxyuridine-1'-13C | 478510-85-9 | 5 MG
2'-Deoxyuridine-1'-13C is a carbon-13 labeled version of 2'-Deoxyuridine. This compound induces chromosome breakage, thereby reducing the synthesis activity of thymidylate. Additionally, it serves as a precursor in the synthesis of Edoxudine.
- Carbon-13 labeled version of 2'-Deoxyuridine.
- Induces chromosome breakage.
- Reduces synthesis activity of thymidylate.
- Serves as a precursor in the synthesis of Edoxudine.
Medchemexpress LLC 2'-Deoxyuridine-1'-13C | 478510-85-9 | 1MG
2'-Deoxyuridine-1'-13C is a stable isotope-labeled compound with the molecular formula C813CH12N2O5 and a molecular weight of 229.19. It appears as a white to off-white solid with an isotopic enrichment of 99%. This product is intended for research use only and has not been fully validated for medical applications.
- White to off-white solid appearance
- Isotopic enrichment of 99%
- Molecular formula C813CH12N2O5
- Intended for research use only
- Store powder at -20°C for up to 3 years or at 4°C for up to 2 years
- Store in solvent at -80°C for 6 months or at -20°C for 1 month
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | MFCD00006547 | 99.95% | 25 G
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and is utilized in cancer research.
- Inhibits biological effects of Bromodeoxyuridine (Brdu)
- Essential for nucleic acid synthesis
- Utilized in cancer research
- Acts as a human endogenous metabolite
- Functions as a microbial metabolite
- Demonstrated to inhibit tumor growth in vivo